9/11/25

Kevin Esvelt: Protein Evolution, Gene Drives & Engineered Viruses | Frameshifts Ep. 1

What if evolution could be sped up a million times faster than in nature, and harnessed to solve some of the world’s toughest challenges, from pandemics to agriculture? This isn’t science fiction. It’s the real science behind synthetic biology tools like PACE (Phage-Assisted Continuous Evolution) and gene drives. In this episode, we sit down with pioneering synthetic biologist Kevin Esvelt to explore how these groundbreaking technologies could:

  • Eradicate malaria-carrying mosquitoes

  • Eliminate parasitic diseases like schistosomiasis

  • Protect crops from destructive pests

  • Engineer next-generation gene editors that might one day cure genetic diseases

But with incredible promise comes ethical risk. Kevin challenges us to consider the dangers of synthetic biology, especially as AI makes both constructive and destructive applications of biotechnology more accessible than ever.

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Space Travel, AI, and Immortality — Peter Diamandis | Frameshifts Ep. 7

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Ron Weiss: Synthetic Biology, Gene Circuits and Programmable Therapies | Frameshifts Ep. 2